Which statement about detector response factor usage in multi-analyte quantitation is true?

Which statement about detector response factor usage in multi-analyte quantitation is true?

• A. They eliminate the need for calibration.
• B. They adjust injection volume.
• C. They help compare responses of different analytes to a single reference signal, enabling accurate quantitation when detector responses vary among analytes.
• D. They are used only in GC, not LC-MS.

Answer: (C)