Define LOD and LOQ and explain how they differ from calibration range.

Define LOD and LOQ and explain how they differ from calibration range.

• A. LOD is the maximum concentration detectable with acceptable signal-to-noise.
• B. LOQ is the same as LOD.
• C. Calibration range is unrelated to detector response.
• D. LOD is the lowest concentration detectable with acceptable signal-to-noise; LOQ is the lowest concentration quantifiable with acceptable accuracy and precision; calibration range is the concentration span over which the detector response is linear and validated.

Answer: (D)